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Updated: Sep 9, 2025

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Center-surround processing in psychosis.

Samantha A Montoya1, Hannah R Moser2, Rohit S Kamath2

  • 1Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN.

Medrxiv : the Preprint Server for Health Sciences
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

People with psychotic psychopathology show altered visual processing, specifically weaker surround suppression in some brain areas but not others. This suggests subtle differences in how the brain processes visual context, potentially impacting neural reliability in schizophrenia.

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Area of Science:

  • Neuroscience
  • Visual Perception
  • Psychopathology

Background:

  • People with psychotic psychopathology (PwPP) exhibit altered visual perception.
  • Contrast surround suppression is a visual illusion where surrounding patterns reduce the perceived contrast of a central pattern.
  • PwPP typically show weaker contrast suppression than controls, but underlying mechanisms remain unclear.

Purpose of the Study:

  • To investigate perceptual and neural surround suppression in controls, relatives of PwPP, and PwPP.
  • To explore neural mechanisms contributing to diminished surround suppression using fMRI and MR spectroscopy.
  • To assess GABA concentration in occipital cortex and its relation to visual processing.

Main Methods:

  • Assessed surround suppression in 38 controls, 44 relatives, and 64 PwPP.
  • Quantified contrast discrimination thresholds and 7 tesla fMRI responses in LGN, V1, and LOC.
  • Measured occipital GABA concentration using 7 T MR spectroscopy.

Main Results:

  • LOC showed weaker surround suppression in PwPP and relatives compared to controls.
  • No significant differences in V1 surround suppression strength were found across groups.
  • No behavioral evidence of reduced surround suppression in PwPP; suppression metrics did not correlate with GABA or symptoms.
  • V1 fMRI revealed group differences in decoding surround context, with lower accuracy in PwPP.

Conclusions:

  • Subtle differences in visual center-surround processing exist in people with schizophrenia.
  • Discrepancies with prior studies may stem from task design or attentional differences.
  • Poorer decoding of center vs. surround in V1 suggests less reliable neural representations of spatial context in PwPP.