[Chorea and systemic lupus erythematosus with circulating anticoagulant. 3 cases]
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Antiphospholipid antibodies were found in young women with systemic lupus erythematosus and chorea. These antibodies may play a role in chorea through thrombotic or autoimmune encephalitis mechanisms.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Chorea is a neurological disorder characterized by involuntary, irregular, and purposeless movements.
- Antiphospholipid antibodies are associated with an increased risk of thrombosis and pregnancy morbidity.
Observation:
- Three young women with SLE presented with choreic manifestations.
- Two of these patients exhibited false-positive syphilitic serology.
- The presence of antiphospholipid antibodies was confirmed in these cases.
Findings:
- A high prevalence of antiphospholipid antibodies was noted in patients with lupus chorea, supported by a literature review of 41 cases.
- The study identified a significant association between antiphospholipid antibodies and chorea in SLE patients.
Implications:
- Antiphospholipid antibodies may have a pathogenic role in chorea associated with SLE.
- Potential mechanisms include thrombotic events or autoimmune encephalitis.
- Further research is warranted to elucidate the precise role of these antibodies in lupus chorea.
Abstract:
Circulating anticoagulant was detected during the course of choreic manifestations in three young women with systemic lupus erythematosus, associated in two cases with false syphilitic serology due to the presence of antiphospholipid antibodies. The high prevalence of the presence of these antibodies in lupic chorea was confirmed by reports of 41 cases in the literature. These findings could suggest a possible pathogenic role for these antibodies in choreic manifestations by either a thrombotic or auto-immune encephalitis mechanism.