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Related Experiment Video

Updated: Sep 9, 2025

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain.

Nisha Hemandhar-Kumar^1,2, Verena Kluever¹, Svenja V Kaufmann^3,4

¹Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.

Biorxiv : the Preprint Server for Biology

|September 2, 2025

Summary

This summary is machine-generated.

Aging brains show molecular changes affecting protein function and cellular processes, increasing neurodegeneration risk. This study reveals key differences between normal brain aging and disease, offering insights into protective strategies.

Keywords:

Proteo-transcriptome analysis multiomics data integration neurodegeneration nuclear retention protein aggregation proteostasis

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Published on: May 22, 2021

Area of Science:

Neuroscience
Molecular Biology
Gerontology

Background:

Brain aging is a significant risk factor for neurodegenerative diseases.
The molecular mechanisms driving brain aging and neurodegeneration are not fully understood.

Purpose of the Study:

To investigate the molecular signatures of brain aging using an integrative proteo-transcriptomic approach.
To compare molecular changes in physiological aging with models of premature aging and neurodegeneration.

Main Methods:

Integrative proteo-transcriptomic analysis of aging mouse brains.
Assessment of protein aggregation, mRNA relocalization, and comparative proteomics.
Analysis across eight models of premature aging and neurodegeneration.

Main Results:

Identified dynamic changes in synaptic maintenance and energy allocation during physiological aging.
Observed decreased mitochondrial complex I proteins without mRNA compensation and impaired translation efficiency due to 60S ribosome subunit aggregation.
Revealed key similarities and differences between physiological aging and neurodegenerative pathology.

Conclusions:

Molecular aging involves changes in protein biochemical properties, mitochondrial function, and translation efficiency.
Understanding these aging mechanisms provides insights into pathways predisposing to neurodegeneration.
The Brain Aging and Molecular Atlas Project (BrainAging-MAP) offers an accessible resource for brain aging research.