Role of gut microbiota and derived metabolites in cardiovascular diseases

Area of Science:

• Microbiology
• Cardiology
• Metabolomics

Background:

• Cardiovascular diseases (CVDs) are a leading global cause of mortality.
• The gut microbiota's role in host physiology and disease is increasingly recognized.
• Emerging evidence links gut microbiota alterations to CVD development.

Purpose of the Study:

• To provide a comprehensive review of the gut microbiota's influence on CVDs.
• To explore the mechanisms by which gut microbes and metabolites contribute to CVDs.
• To discuss the therapeutic potential of targeting the gut microbiota for CVD treatment.

Main Methods:

• Literature review of studies on gut microbiota and cardiovascular diseases.
• Analysis of direct and indirect mechanisms of gut microbiota involvement in CVDs.
• Synthesis of current research on microbial metabolites and their cardiovascular effects.

Main Results:

• Gut microbiota composition and function directly impact CVD processes.
• Microbial metabolites play a crucial role in the pathogenesis of CVDs.
• Specific gut microbes and their metabolites are associated with CVD risk and progression.

Conclusions:

• The gut microbiota is a significant factor in the development and progression of cardiovascular diseases.
• Targeting the gut microbiota presents a novel therapeutic avenue for CVD management.
• Future research should focus on elucidating specific microbial targets for clinical intervention in CVDs.