Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Radiological Investigation I: X-ray and CT

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Imaging lymphatic function and inflammation response through hypoxia via endogenous biomarker.

Journal of biomedical optics·2025

Same author

Wavelet-informed deep video denoising for Cherenkov imaging of radiation therapy.

Optics letters·2025

Same author

Intermediate tissue oxygen level is required to observe murine FLASH skin sparing.

bioRxiv : the preprint server for biology·2025

Same author

Cherenkov emission in realistic optical body phantoms to study effects of skin tone on imaging delivery technique.

Physics in medicine and biology·2025

Same author

FLASH effect is diminished by daily fractionation of electron RT in mouse skin.

Physics in medicine and biology·2025

Same author

Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities.

Journal of biomedical optics·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast

Yao Chen¹, Savannah M Decker¹, Petr Bruza¹

¹Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire.

|September 2, 2025

Summary

This study introduces Cherenkov imaging to track patient positioning during radiation therapy, improving accuracy for breast cancer treatment by quantifying loco-regional tissue deformation. This novel method enhances precision for inter/intrafraction positioning.

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Area of Science:

Medical Physics
Radiation Oncology
Biomedical Imaging

Background:

Accurate patient positioning is critical for effective radiation therapy, as positioning errors significantly impact treatment outcomes.
Quantifying loco-regional tissue deformation during radiation therapy remains a challenge with current imaging techniques.

Purpose of the Study:

To develop and validate an algorithmic method using Cherenkov image analysis for quantifying loco-regional tissue deformation and patient positioning accuracy.
To assess the feasibility of Cherenkov-based tracking for improving inter- and intrafraction positioning in breast cancer radiation therapy.

Main Methods:

Cherenkov images were analyzed, segmenting bio-morphological features like vessels.
A combined rigid/nonrigid registration technique was used to quantify both global shifts and local tissue deformations.
The method was validated using an anthropomorphic chest phantom and applied to clinical data from 10 breast cancer patients.

Main Results:

Phantom experiments demonstrated high accuracy (0.83 mm) for couch translations.
Clinical data revealed interfraction setup variations of 3.7 ± 2.4 mm (global shift) and up to 3.3 ± 1.9 mm (95th percentile loco-regional deformation).

Conclusions:

Cherenkov imaging with rigid/nonrigid registration effectively quantifies global and local patient positioning variations.
This novel approach offers quantitative guidance for inter/intrafraction positioning, addressing previously unappreciated loco-regional deformations.