Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• The Hippo pathway is vital for cellular processes but its dysregulation is linked to multiple cancer types.
• Effective cancer therapies are urgently needed due to the global rise in cancer deaths.
• Existing research on targeting the Hippo pathway for cancer treatment requires comprehensive integration.

Purpose of the Study:

• To review the potential of targeting the Hippo/yes-associated protein (YAP) pathway for cancer therapy.
• To provide insights into the molecular mechanisms of the Hippo pathway in physiological and cancer conditions.
• To consolidate information on natural and synthetic compounds targeting the Hippo pathway.

Main Methods:

• Literature review of molecular mechanisms of the Hippo signaling pathway.
• Overview of natural products and synthetic compounds targeting the Hippo pathway.
• Analysis of preclinical and clinical studies on Hippo pathway inhibitors in cancer.

Main Results:

• The Hippo/YAP pathway plays a significant role in the development of various cancers.
• Numerous natural products and synthetic compounds show potential for targeting the Hippo pathway.
• Preclinical and clinical data suggest the efficacy of these compounds in cancer treatment.

Conclusions:

• Targeting the Hippo/YAP pathway presents a promising therapeutic strategy for a wide range of cancers.
• Further research into natural and synthetic compounds modulating this pathway is warranted.
• This review highlights the therapeutic potential of Hippo pathway inhibitors in oncology.