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Updated: Sep 9, 2025

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Shape memory hydrogels in tissue engineering: Recent advances and challenges.

Abid Naeem1,2,3,4, Chengqun Yu5, Lili Zhou6

  • 1School of Life Science, School of Interdisciplinary Science, Aerospace Center Hospital, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, PR China.

Bioactive Materials
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

Shape memory hydrogels (SMHs) offer advanced solutions in tissue engineering due to their shape recovery ability. This review explores their design, properties, and applications in regenerative medicine, despite existing challenges.

Keywords:
3D-printed customized implantsShape memory hydrogelsSmart drug delivery systemsSoft tissue reconstructionTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Shape memory hydrogels (SMHs) possess unique properties like hydrophilicity, elasticity, and shape recovery after deformation.
  • These characteristics make them highly suitable for diverse biomedical applications, particularly in tissue engineering.

Purpose of the Study:

  • To review the innovative design and synthesis of SMHs.
  • To highlight the physical and biological properties relevant to tissue engineering.
  • To explore the diverse applications and persistent challenges of SMHs.

Main Methods:

  • Review of existing literature on SMH design and synthesis.
  • Analysis of physical and biological characteristics of SMHs.
  • Examination of SMH applications in tissue regeneration, drug delivery, and implant fabrication.

Main Results:

  • SMHs exhibit tunable mechanical properties, biocompatibility, and biodegradability.
  • Key applications include bone, soft tissue, vascular, and neural tissue engineering, as well as smart drug delivery and 3D-printed implants.
  • Challenges include scalability, property optimization, shape fixation, degradation control, and long-term stability.

Conclusions:

  • SMHs present innovative solutions for complex biomedical challenges.
  • Further interdisciplinary research is crucial to overcome limitations and enhance clinical potential.
  • SMHs are valuable tools for advancing regenerative medicine and improving patient outcomes.