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Mechanical and kinematic alignment in total knee arthroplasty: A comparative study on sizing discrepancies
Jakub Gocal1, Amy Wozniak1,2, Michael Murphy2
1Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Journal of Orthopaedics
|September 2, 2025
Summary
Kinematic alignment in total knee arthroplasty (TKA) significantly impacts femoral and tibial component sizing compared to mechanical alignment. Understanding these differences is crucial for optimizing implant selection and patient outcomes.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
- Knee biomechanics
Background:
- Total knee arthroplasty (TKA) aims to restore knee function.
- Kinematic alignment (KA) seeks to replicate pre-arthritic anatomy, contrasting with mechanical alignment (MA) which follows the mechanical axis.
- Accurate prosthesis sizing is vital for optimal TKA outcomes, but MA-based systems may pose challenges for KA.
Purpose of the Study:
- To investigate discrepancies in femoral and tibial prosthesis sizing between KA and MA in primary TKA.
- To determine if inherent differences in alignment philosophies affect component selection.
Main Methods:
- Retrospective analysis of 324 primary TKA cases.
- Categorization into KA and MA groups.
- Comparison of predicted versus implanted component sizes, analyzing discrepancies.
Main Results:
- KA demonstrated a higher incidence of smaller femoral components relative to tibial components (10.7% vs. 1.4%) and equal-sized components (51.1% vs. 28.8%) compared to MA.
- MA resulted in a greater proportion of larger femoral components (69.9% vs. 38.2%).
- KA was associated with smaller femoral implants, with predicted sizes exceeding actual sizes more frequently (68.7% vs. 53.6%).
Conclusions:
- Femoral component sizing distributions differ significantly between KA and MA techniques.
- Alignment strategy must be considered in TKA component design and selection.
- Recognizing these sizing variations is essential for optimizing implant selection and improving TKA outcomes as KA adoption grows.

