Reverse Remodeling Induced by Transcatheter Left Ventricular Restoration System Is Sustained Through 2 Years of
Alena Kurlianskaya1, Michael L Chuang2, Oleg Polonetsky1
1Cardiology, Republican Scientific and Practical Center Cardiology, Minsk, Belarus.
Structural Heart : the Journal of the Heart Team
|September 2, 2025
Summary
The Transcatheter Left Ventricular Restoration System initially reduces heart size, followed by biological reverse remodeling. This improves heart function and quality of life for heart failure patients.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure Research
Background:
- Heart failure often involves structural changes like reduced left ventricular volume.
- Effective treatments are needed to reverse adverse cardiac remodeling.
- Transcatheter interventions offer less invasive approaches to cardiac repair.
Purpose of the Study:
- To evaluate the long-term structural and functional changes after Transcatheter Left Ventricular Restoration.
- To assess the impact of the device on heart failure medical therapy and quality of life.
Main Methods:
- Utilizing the Transcatheter Left Ventricular Restoration System.
- Monitoring left ventricular end-diastolic volume and ejection fraction over time.
- Assessing changes in heart failure medical therapy and patient quality of life.
Main Results:
- Initial decrease in left ventricular end-diastolic volume followed by reverse remodeling up to 2 years.
- Absolute increase of approximately 5% in left ventricular ejection fraction.
- Minimal changes in concomitant heart failure medical therapy.
- Reported improvements in quality of life, noted within an unblinded study context.
Conclusions:
- Transcatheter Left Ventricular Restoration induces sustained reverse remodeling and improves ejection fraction.
- The procedure demonstrates potential for enhancing quality of life in heart failure patients.
- Further blinded studies are warranted to confirm quality of life improvements.
