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Updated: Sep 9, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Herpes Simplex Virus Type-1 Infection as a Trigger for Pemphigus Vulgaris
Ana Toste1,2, Humberto Machado3, João C Almeida4,2
1Internal Medicine Department, Unidade Local de Saúde de São João, Porto, PRT.
None:
Pemphigus vulgaris (PV) is a mucocutaneous autoimmune disorder that can be challenging to diagnose and treat. We discuss a clinical case of a patient with a previous medical history of autoimmune gastritis and vitiligo who presented with painful oral ulceration but was devoid of dermatological manifestations. Immunoglobulin M (IgM) antibodies and polymerase chain reaction (PCR) amplification of Herpes simplex virus type 1 (HSV-1) were detected from the base of the ulcers. Treatment with acyclovir only modestly improved the lesions. Anti-desmosome antibodies were positive, and an oral biopsy showed PV features. Treatment with prednisolone followed by rituximab (RTX) resulted in significant improvement.
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