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Transplanted Cells, Transferred Minds: Can Transplanted Cells Influence Mental Illness?

V Tsytsarev1, A B Volnova2, M Y Inyushin3

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Summary

Emerging evidence suggests transmissible mechanisms may influence schizophrenia and other mental disorders, challenging previous assumptions about their non-communicable nature. Research into these pathways is vital for understanding disease and developing new treatments.

Keywords:
bone marrowcell transplantationpsychosis, mental disordersschizophreniastem cells

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Mental disorders like schizophrenia show complex genetic influences but also unknown contributors.
  • Historically, major psychiatric disorders were not considered transmissible.
  • Recent findings challenge this, suggesting potential transmission routes.

Purpose of the Study:

  • To review current research on transmissible mechanisms in schizophrenia and neuropsychiatric disorders.
  • To explore how these findings can inform novel therapeutic strategies.

Main Methods:

  • Review of existing literature and case reports.
  • Analysis of findings from bone marrow transplant studies.
  • Examination of evidence from experimental animal models.

Main Results:

  • Reports of schizophrenia-like symptoms post-transplant from affected donors.
  • Cases of remission in schizophrenia patients after transplant from unaffected donors.
  • Animal models suggest non-genotypic mechanisms can initiate or suppress pathology.

Conclusions:

  • Transmissible mechanisms, though not altering recipient genotype, may play a role in neuropsychiatric disorders.
  • The biological basis for these effects is not yet fully understood.
  • Further research is critical for understanding pathogenesis and developing innovative therapies.