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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

207
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
207

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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Exploring Visuo-Tactile Temporal Binding Window Plasticity in Obsessive-Compulsive Disorder.

Francesca Rastelli1, Davide Fausto Borrelli2, Francesca Ferroni1

  • 1Department of Medicine and Surgery, Unit of Neuroscience, University of Parma, Parma, Italy.

Biological Psychiatry Global Open Science
|September 2, 2025
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Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) is linked to wider temporal binding windows (TBW), affecting how the brain integrates sensory information. Patients with OCD showed greater improvement after training designed to narrow their TBW.

Keywords:
LearningMultisensory integrationPrediction errorPriorsPsychiatry

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Multisensory integration (MSI) relies on temporal boundaries, particularly the temporal binding window (TBW), for event perception.
  • TBW plasticity, the ability to narrow the TBW through training, is altered in neuropsychiatric conditions.
  • Obsessive-compulsive disorder (OCD) may involve wider MSI temporal boundaries due to heightened uncertainty and reliance on real-time sensory input.

Purpose of the Study:

  • To investigate temporal binding window (TBW) plasticity in individuals with obsessive-compulsive disorder (OCD).
  • To compare TBW and its plasticity between patients with OCD and healthy controls.

Main Methods:

  • A simultaneity judgment task was administered to 31 patients with OCD and 34 healthy controls.
  • Participants completed the task before and after a perceptual training session aimed at narrowing the temporal binding window (TBW).
  • The study assessed TBW size and training-induced changes in TBW plasticity.

Main Results:

  • Patients with OCD exhibited a larger temporal binding window (TBW) and abnormal tactile leading dominance pre-training compared to controls.
  • Individuals with OCD demonstrated significantly higher training gain, indicating greater plasticity in narrowing their TBW.
  • These findings highlight altered temporal processing in OCD.

Conclusions:

  • Altered temporal binding window (TBW) plasticity in OCD may stem from difficulties utilizing past experiences and an over-reliance on immediate sensory data.
  • Understanding these multisensory integration (MSI) alterations offers insights into OCD's sensory underpinnings.
  • Findings may guide the development of novel sensory-based interventions for OCD.