A Case of Asymptomatic Cronkhite-Canada Syndrome Diagnosed by Endoscopic and Pathological Findings

Cronkhite-Canada syndrome (CCS) is a rare, non-hereditary disease characterized by specific symptoms, ectodermal abnormalities, endoscopic findings, and pathological examination. We report a unique case of a 39-year-old man with suspicious CCS. Although the blood test showed iron-deficiency anemia and hypoalbuminemia, he exhibited no symptoms, including those related to CCS itself and anemia and hypoalbuminemia. According to the result of endoscopic and pathological examination, he was diagnosed with possible CCS. While following the patient's medical course, the serum albumin level gradually declined. Six months after the diagnosis, oral corticosteroid therapy was initiated to prevent disease progression. Consequently, the patient achieved a favorable clinical course without developing any symptoms. This case highlights the importance of considering CCS even in the absence of typical symptoms and suggests that therapeutic intervention may be beneficial even in asymptomatic presentations.