Diffuse Normolipemic Plane Xanthoma Associated With Monoclonal Gammopathy

Area of Science:

• Dermatology
• Hematology
• Pathology

Background:

• Diffuse normolipidemic plane xanthoma is a rare acquired non-Langerhans histiocytosis subtype.
• It is frequently associated with underlying hematologic disorders, particularly lymphoproliferative disorders.

Observation:

• A case report details a 52-year-old woman with asymptomatic, yellowish plaques on the eyelids, neck, axillae, back, and thighs over two years.
• Skin biopsy confirmed plane xanthoma.
• Laboratory tests revealed normal lipids but elevated serum IgG and a monoclonal band.

Findings:

• The patient was diagnosed with monoclonal gammopathy of undetermined significance (MGUS).
• This diagnosis was established after comprehensive hematologic workup.

Implications:

• This case underscores the association between normolipidemic plane xanthoma and MGUS.
• It emphasizes the need for thorough hematologic evaluation in patients presenting with this dermatosis.
• Continued monitoring in dermatology and hematology is crucial for managing potential disease progression.