A Comprehensive Review of Food-Derived Compounds Targeting Pyroptosis for Colitis Therapy: From Effects to Mechanisms

Area of Science:

• Gastroenterology
• Immunology
• Pharmacology

Background:

• Ulcerative colitis (UC) is an inflammatory bowel disease with incompletely understood pathology, complicating treatment.
• Pyroptosis, a pro-inflammatory programmed cell death, is mediated by Gasdermin D and involves caspase pathways.
• Dysregulated pyroptosis signaling is linked to UC progression, suggesting it as a therapeutic target.

Purpose of the Study:

• To review pyroptosis pathways (classical, non-classical, alternative) and their role in UC.
• To explore the therapeutic potential of food-derived compounds in modulating pyroptosis for UC.
• To inform the development of novel pharmacological interventions for UC.

Main Methods:

• Literature review of pyroptosis mechanisms and pathways.
• Analysis of studies on natural compounds targeting programmed cell death in UC.
• Examination of pyroptosis signaling in UC pathogenesis and treatment.

Main Results:

• Pyroptosis activation is implicated in UC pathogenesis.
• Natural compounds show potential in modulating pyroptosis-related targets.
• Targeting pyroptosis offers a promising therapeutic avenue for UC.

Conclusions:

• Understanding pyroptosis pathways is crucial for UC treatment.
• Food-derived compounds represent a potential therapeutic strategy for UC by targeting pyroptosis.
• Further research into natural compounds can lead to new UC pharmacological interventions.