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Conducting multicenter simulation-based experimental research: lessons drawn from the Quality CPR European project.

Carla Sa-Couto1, Christoffer Ericsson2, Marc Lazarovici3

  • 1RISE-Health, Community Medicine, Information and Decision Sciences Department (MEDCIDS), Faculty of Medicine, University of Porto (FMUP), Porto, Portugal.

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Summary

Conducting international multicenter studies requires careful planning and execution. This research shares twelve practical lessons learned from the Quality CPR European study to improve future cross-institutional health research.

Keywords:
Experimental designInternational collaborationMulticenter studiesPractical guidanceResearchSimulation

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Area of Science:

  • Cardiology
  • Medical Education
  • Health Services Research

Background:

  • Multicenter research enhances generalizability but poses international challenges.
  • International experimental studies require robust methodological and operational strategies.
  • The Quality CPR study addressed these challenges in a European multicenter simulation.

Purpose of the Study:

  • To reflect on the practical experiences of designing and implementing an international multicenter simulation-based study.
  • To identify and share key lessons learned across the research lifecycle.
  • To provide a practical reference for researchers planning similar cross-institutional initiatives.

Main Methods:

  • A European multicenter simulation-based experimental study (Quality CPR).
  • Randomized crossover design across academic institutions in Portugal, Germany, and Finland.
  • Investigation of factors influencing chest compression quality and rescuer fatigue during simulated cardiopulmonary resuscitation.

Main Results:

  • Twelve key lessons were identified across planning, development, execution, and dissemination phases.
  • Collaborative protocol design and a researcher guide were crucial for harmonization.
  • Active support, real-time data monitoring, and integrated dissemination were enablers of success.

Conclusions:

  • Successful international multicenter studies depend on meticulous planning and adaptive execution.
  • Documenting practical lessons learned facilitates knowledge sharing and improves future research endeavors.
  • This paper offers valuable insights for healthcare researchers involved in cross-institutional collaborations.