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Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Disseminated Adenovirus Infection in Renal Transplant Recipients
Karthik Sunder1, M Navya1, Jui Athavale2
1Department of Nephrology, Apollo Hospitals, Greams Lane, Chennai, Tamil Nadu, India.
Indian Journal of Nephrology
|September 2, 2025
Summary
Disseminated adenovirus infection is rare in renal transplant recipients and often overlooked. Reducing immunosuppression effectively treated two patients with fever and adenovirus infection.
Area of Science:
- Nephrology
- Virology
- Immunology
Background:
- Renal transplantation is a critical treatment for end-stage renal disease.
- Adenoviruses are DNA viruses that can cause opportunistic infections in immunocompromised individuals.
Observation:
- Two renal transplant recipients presented with fever, a common symptom in post-transplant patients.
- Disseminated adenovirus infection was diagnosed in both patients, suggesting a potential complication of immunosuppression.
Findings:
- Adenovirus infections in renal transplant recipients are uncommon and can lead to graft dysfunction.
- Treatment involved a reduction in immunosuppressive therapy, leading to viral clearance and symptom resolution.
Implications:
- This case highlights the importance of considering disseminated adenovirus infection in febrile renal transplant recipients.
- Adjusting immunosuppression levels may be a key therapeutic strategy for managing adenovirus infections in this population.
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