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Published on: April 15, 2014
[Idiopathic eosinophilic meningoencephalomyelitis in a young Belgian Tervueren-shepherd dog]
Sabrina Pahl1, Jan Christian Wohlsein2, Svenja Becker1
1Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover.
Abstract:
Eosinophilic meningoencephalitis is a rare neurological disorder, affecting mainly young, male and medium-sized to large breed dogs. This case report describes the clinical signs of a grave and peracute clinical course and pathomorphological findings of a young, female Belgian Tervueren shepherd dog with eosinophilic meningoencephalomyelitis. The dog was presented to emergency service with acute onset of progressive apathy, developing into stupor and lateral recumbency. Despite immediate symptomatic treatment deteriorating consciousness with tetraparesis was noted and finally the dog went into coma associated with decerebrate rigidity. The dog was humanly euthanized on request of the owner 7 hours after presentation in the clinic. Gross pathological examination revealed circumscribed lesions particularly in the white matter of the cerebral cortex. Histologically, a multifocal severe, eosinophilic and granulomatous to necrotizing and lymphohistiocytic meningoencephalomyelitis was observed. In both adrenal glands, a severe eosinophilic and granulomatous inflammation was detected in the medulla. The etiopathogenesis remained undefined and the encephalitis was categorized as "meningoencephalomyelitis of unknown origin" (MUO).
Insights
This case report details a fatal eosinophilic meningoencephalomyelitis in a young Belgian Tervueren. The rare canine neurological disorder presented peracutely, leading to rapid deterioration and coma.
Area of Science:
- Veterinary Neurology
- Canine Pathology
Background:
- Eosinophilic meningoencephalitis is a rare neurological disorder predominantly affecting young, male, medium to large breed dogs.
- This report focuses on a specific case in a young female Belgian Tervueren shepherd dog.
Purpose of the Study:
- To describe the clinical signs and pathomorphological findings of eosinophilic meningoencephalomyelitis in a young Belgian Tervueren.
- To document the peracute clinical course and diagnostic observations of this rare canine neurological disorder.
Main Methods:
- Case report detailing clinical presentation, emergency treatment, and outcome.
- Gross pathological examination of the brain and adrenal glands.
- Histopathological analysis of affected tissues to characterize the inflammation.
Main Results:
- The dog exhibited a peracute onset of apathy, stupor, lateral recumbency, tetraparesis, coma, and decerebrate rigidity.
- Gross examination revealed lesions in the cerebral cortex white matter.
- Histopathology confirmed severe, multifocal eosinophilic and granulomatous to necrotizing lymphohistiocytic meningoencephalomyelitis and adrenal medullary inflammation.
Conclusions:
- The case presented with a grave and peracute clinical course, consistent with severe meningoencephalomyelitis.
- The etiopathogenesis remained undefined, classifying the condition as meningoencephalomyelitis of unknown origin (MUO).
- This case highlights the severe presentation and diagnostic challenges of this rare canine neurological disease.
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