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FungiSNC: An integrated database for fungi small non-coding RNAs based on high-throughput sequencing
Xiaoqiang Lang1, Jinjing Luo2, Fazhi Li1
1Microbiology and intelligent biomanufacturing Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, Sichuan 610041, China.
Journal of Advanced Research
|September 2, 2025
Summary
FungiSNC is the first integrated database for fungal small non-coding RNAs (sncRNAs), offering comprehensive analysis tools. This platform aids in understanding sncRNA functions and regulatory networks in fungi for antifungal and biocontrol applications.
Area of Science:
- Mycology
- Bioinformatics
- Genomics
Background:
- Small non-coding RNAs (sncRNAs) are vital regulators in fungal development, stress responses, and pathogenicity.
- Existing databases lack comprehensive integration and analysis capabilities for fungal sncRNA sequencing data.
- A dedicated platform for fungal sncRNAs and their functions is currently unavailable.
Purpose of the Study:
- To establish FungiSNC, the first integrated database for fungal sncRNAs.
- To provide a comprehensive platform for diverse sncRNA categories in fungi.
- To facilitate the analysis and exploration of fungal sncRNA functions.
Main Methods:
- Standardized workflow for data preprocessing of public and in-house sRNA-seq datasets.
- Systematic detection, classification, and functional annotation of sncRNAs.
- Integration of results into a relational database with embedded analytical tools.
Main Results:
- FungiSNC is presented as an integrated database for fungal sncRNAs.
- It encompasses diverse sncRNA categories: siRNAs, milRNAs, phasiRNAs, rRNAs, tRNAs, snRNAs, snoRNAs, piRNAs, and tRFs.
- The database aggregates 989 NGS samples from 29 fungal species.
Conclusions:
- FungiSNC is the inaugural platform for fungal sncRNA data curation, annotation, and functional analysis.
- It bridges fragmented data with computational tools to explore sncRNA regulatory networks in fungi.
- Findings have implications for antifungal therapy and agricultural biocontrol strategies.
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