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Optimizing hypertension treatment: Evidence-based approaches and new drugs

Astefanos Al-Dalakta1, Ahmad Ghanem2, Chadi Tabaja1

  • 1Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.

Cleveland Clinic Journal of Medicine
|September 2, 2025
PubMed

Insights

Poor blood pressure control is common. This review covers evidence-based hypertension management and new strategies to optimize blood pressure and reduce cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Public Health

Background:

  • Despite therapeutic advancements, suboptimal blood pressure management persists globally.
  • Hypertension is a major modifiable risk factor for cardiovascular disease (CVD).

Purpose of the Study:

  • To review contemporary evidence-based strategies for hypertension management.
  • To highlight novel therapeutic approaches for optimizing blood pressure control.
  • To reduce the incidence of hypertension-related cardiovascular events.

Main Methods:

  • Review of current medical literature and clinical guidelines.
  • Case-based discussion of hypertension management scenarios.
  • Analysis of emerging treatment modalities.

Main Results:

  • Current guidelines emphasize lifestyle modifications and pharmacotherapy.
  • Combination therapy is often required for resistant hypertension.
  • Newer agents and treatment paradigms show promise.

Conclusions:

  • Optimizing blood pressure control requires a multifaceted, evidence-based approach.
  • Personalized treatment strategies are crucial for managing hypertension effectively.
  • Advances in hypertension management offer improved cardiovascular outcomes.

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