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Updated: Sep 9, 2025
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol
Federico Longhini1, Claudia Crimi2, Alberto Noto3
1Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy flonghini@unicz.it.
Introduction:
Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited. The OxyFOB study aims to assess the prevalence and outcomes of various oxygenation and ventilatory support strategies used during FB across Europe.
Methods And Analysis:
The OxyFOB study is a large, prospective, international, observational cohort study which aims to involve over 10 000 FB procedures across European centres. Eligible participants include all adults undergoing FB for diagnostic, therapeutic or procedural indications. Data are collected via a standardised electronic case report form and encompass demographic information, procedural details and clinical outcomes. The primary endpoint is the prevalence of oxygenation and ventilatory support strategies: conventional oxygen therapy, high-flow oxygen therapy, continuous positive airway pressure, non-invasive ventilation and invasive mechanical ventilation. Secondary outcomes include periprocedural respiratory and haemodynamic events, patient comfort, dyspnoea and postprocedural complications. Statistical analyses include descriptive statistics, subgroup comparisons and multivariate logistic regression.
Ethics And Dissemination:
The study has received ethical approval from the coordinating centre (protocol n. 22/2022 on the 20 January 2022, by the 'Comitato Etico Sezione Area Centro - Regione Calabria') and all participating sites. Informed consent is given from all patients or their legal representatives. Findings will be disseminated through peer-reviewed publications and presentations at international meetings. Data will be managed and made available on reasonable request to support further research.
Trial Registration Number:
ClinicalTrials.gov ID: NCT05681962. Registered January 2023.
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