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Updated: Sep 9, 2025

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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Factors Affecting Quality Control (QC) Failure Rates in Somatic Breast Cancer (BRCA) Gene Testing in Castrate

Cian O'Leary1, Edward Yoong1, Admire Matsika2

  • 1Mater Cancer Care Centre, Mater Hospital Brisbane, Brisbane, Queensland, Australia.

Asia-Pacific Journal of Clinical Oncology
|September 2, 2025
PubMed
Summary

Somatic BRCA testing in castrate-resistant prostate cancer (CRPC) can fail due to older tissue samples. A longer time from biopsy to testing increases inconclusive results, suggesting repeat biopsies for samples over 5 years old.

Keywords:
BRCAprostate cancerquality improvementsomatic testing

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