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Research and advances in mouse models of diabetic nephropathy: a narrative review

Kang Xie1, Yan Ma2, Jingjing Din2

  • 1Department of Endocrinology, Yijishan Hospital, Wannan Medical College, Wuhu, 241000, China.

BMC Nephrology
|September 2, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Animal modelDiabetic nephropathyMice

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Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...