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Prognostic value of risk factors in cervical squamous cell carcinoma based on tumour infiltration depth

  • 0Department of Gastroenterology, Shanxi Provincial Cancer Hospital, No. 3, Employee New Street, Xinghualing District, Taiyuan, 030013, China.
Bmc Cancer +

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September 2, 2025

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September 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Tumour infiltration depth impacts cervical cancer prognosis. While lymph node metastasis is always a risk, factors like tumour volume and vaginal invasion become more significant with deeper infiltration, guiding treatment decisions.

Area Of Science

  • Gynecologic Oncology
  • Cancer Research
  • Pathology

Background

  • Cervical squamous cell carcinoma prognosis is influenced by various risk factors.
  • The prognostic significance of these factors may vary based on tumour infiltration depth.

Purpose Of The Study

  • To determine if the prognostic importance of risk factors differs according to tumour infiltration depth in cervical squamous cell carcinoma.
  • To identify key prognostic indicators for patient stratification and treatment planning.

Main Methods

  • Retrospective cohort study of 621 cervical squamous cell carcinoma patients.
  • Patients classified into two groups based on stromal wall infiltration: complete (Group 1) vs. partial (Group 2).
  • Multivariate Cox regression survival analysis to identify independent prognostic factors.

Main Results

  • In complete infiltration (Group 1), tumour volume (>30.8 cm³), lymph node metastasis, and vaginal invasion were independent prognostic factors for 5-year survival.
  • In partial infiltration (Group 2), only lymph node metastasis remained a significant independent prognostic factor for 5-year survival.
  • Lymph node metastasis showed a 290% higher mortality risk in Group 2, while tumour volume and vaginal invasion significantly increased mortality in Group 1.

Conclusions

  • Lymph node metastasis is a consistent independent prognostic factor across all infiltration depths.
  • Tumour volume, vaginal invasion, vascular involvement, and pathological grade gain prognostic significance with increasing tumour infiltration depth.
  • Consider postoperative chemoradiotherapy for patients with serosal infiltration and large tumour volume or vaginal invasion to improve outcomes.

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