High expression of Mrps10 in diabetic retinopathy: A bioinformatics analysis based on public transcriptomic data

Area of Science:

• Ophthalmology
• Genetics
• Bioinformatics

Background:

• Diabetic retinopathy (DR) is a common complication of diabetes, leading to vision loss.
• The molecular mechanisms driving DR pathogenesis are not fully understood.
• Mitochondrial ribosomal protein S10 (Mrps10) gene expression is linked to metabolic disorders.

Purpose of the Study:

• To investigate the expression profile of Mrps10 in diabetic retinopathy.
• To explore the potential molecular mechanisms of Mrps10 in DR pathogenesis.
• To identify Mrps10 as a potential molecular target for DR therapies.

Main Methods:

• Integrated bioinformatics analysis of public transcriptomic data (GSE111465).
• Differential gene expression analysis using the 'limma' package.
• Functional enrichment (GO, KEGG, Metascape), WGCNA, PPI networks, and CTD analysis.

Main Results:

• Mrps10 was significantly overexpressed in retinal tissues of DR patients.
• Functional enrichment linked Mrps10 to mitochondrial dysfunction and oxidative stress.
• PPI and CTD analyses supported Mrps10's regulatory role in DR progression.

Conclusions:

• Mrps10 overexpression may promote DR progression via mitochondrial and oxidative stress pathways.
• Mrps10 represents a potential molecular target for novel DR therapies.
• Further research into Mrps10's biological functions is warranted for therapeutic development.