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Updated: Sep 9, 2025
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and
Heng Zhang1, Yunkai Yang2, Shaohua Liu3
1Department of Endocrinology and Metabolism, General Hospital of The Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, China.
Background:
To assess the clinical benefits of Selenium (Se) supplementation in patients with Hashimoto thyroiditis (HT).
Methods:
Eight databases were searched for randomized controlled trials. The outcomes of interest were thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4). The study protocol is registered on INPLASY, DOI number is 10.37766/inplasy2022.10.0085.
Results:
Twenty-one studies with a total of 1610 subjects were included. Serum TPOAb was significantly reduced after Se supplementation after 3 months (standardized mean difference [SMD] = -0.46, 95% confidence interval [CI]: -0.74 to -0.18, P = .001) and 6 months (SMD = -0.80, 95%CI: -1.38 to -0.21, P = .008). The serum TgAb levels decreased at 3 months (SMD = -0.46, 95%CI: -0.79 to -0.12, P = .007) but not at 6 months. Significant effects on declining the TSH titers were found after 6 months (SMD = -0.18, 95%CI = -0.35 to -0.01; P = .03).
Conclusion:
Se supplementation help reduce TPOAb and TSH levels in HT patients, leading to improvements in well-being or mood. Selenomethionine is more effective than NaSe and Se-yeast in the teatment of Hashimoto thyroid.
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