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Updated: Sep 9, 2025
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Interventional management of chest wall sarcomatoid carcinoma mimicking breast cancer metastasis: A case report
Qiyu Zhang1, Qiongyu Liang1, Jiapeng Sun2
1Department of Interventional Treatment, Beijing No. 6 Hospital, Beijing, China.
Rationale:
Breast cancer patients have an increased risk of developing second primary malignancies, with lung cancer accounting for approximately 5% of cases. Differentiating between metastatic disease and a second primary malignancy remains a diagnostic challenge.
Patient Concerns:
A 45-year-old woman with a history of triple-negative breast cancer presented with a newly detected chest wall nodule during routine follow-up.
Diagnoses:
Contrast-enhanced imaging suggested metastatic disease. However, biopsy and immunohistochemistry confirmed a second primary lesion, consistent with either pulmonary sarcomatoid carcinoma or chest wall sarcoma.
Interventions:
The patient underwent a multimodal interventional regimen, including transarterial embolization followed immediately by radiofrequency ablation.
Outcomes:
At 1 month post-treatment, follow-up imaging demonstrated significant tumor shrinkage with no evidence of local recurrence.
Lessons:
This case underscores the importance of comprehensive diagnostic evaluation to distinguish metastatic disease from second primary malignancies in breast cancer patients. It also highlights the potential of interventional therapy as a minimally invasive treatment option for inoperable tumors, with multidisciplinary management being essential to optimize outcomes and prognosis.
