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Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

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Published on: July 14, 2023

Hierarchically Reinforcing Hydrogel for Multidimensional Bone Homeostasis Modulation to Regenerate Osteoporotic

Tingting Xu¹, Lingbin Che², Lin Du¹

¹College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.

Advanced Healthcare Materials

|September 3, 2025

Summary

This study introduces a novel injectable hydrogel for osteoporotic bone defects, using hierarchical stiffening and alendronate delivery to enhance bone regeneration and homeostasis.

Keywords:

injectable hydrogel osteoclastogenic differentiation osteogenic differentiation shape memory short fibers stiffness

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Osteoporotic bone defects (OBD) require treatments balancing mechanical support and injectability.
Existing hydrogels often compromise mechanical strength for ease of delivery.

Purpose of the Study:

To develop a hierarchically stiffened injectable hydrogel for OBD repair.
To enhance osteogenesis and bone homeostasis through combined strategies.

Main Methods:

Synergistic crosslinking: dynamic hydrazone, chemical double-bond, and shape-memory short fiber (SMSF) contraction.
Photocrosslinking for initial stiffening, followed by thermal activation of SMSFs for further densification.
Incorporation of alendronate (ALN) for enhanced osteogenesis.

Main Results:

Hydrogel stiffness increased hierarchically from 9.27 kPa to 53.40 kPa.
Demonstrated excellent biocompatibility and promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via RhoA/ROCK pathway.
ALN release further boosted osteogenesis and suppressed osteoclastogenesis.

Conclusions:

The injectable hydrogel effectively restores bone homeostasis and accelerates regeneration in osteoporotic defects.
Hierarchical stiffening combined with ALN delivery offers a promising therapeutic strategy for OBD.