Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Short-TR Acquisition Time-of-flight MR Angiography with Deep Learning Reconstruction: Technical Feasibility and Initial Clinical Evaluation in Moyamoya Disease.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine·2026

Same author

Balloon-Assisted <i>n</i>-Butyl Cyanoacrylate Filling of Saccular Portal and Splenic Vein Pseudoaneurysms.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026

Same author

Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan.

Journal of magnetic resonance imaging : JMRI·2025

Same author

Tract embolization with gelatin sponge after percutaneous transhepatic portal vein intervention.

Acta radiologica (Stockholm, Sweden : 1987)·2024

Same author

The Fine-Tuned Large Language Model for Extracting the Progressive Bone Metastasis from Unstructured Radiology Reports.

Journal of imaging informatics in medicine·2024

Same author

Diagnostic performances of Claude 3 Opus and Claude 3.5 Sonnet from patient history and key images in Radiology's "Diagnosis Please" cases.

Japanese journal of radiology·2024

Search research articles

Related Experiment Video

Updated: Sep 9, 2025

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Characterizing Hemodynamic Alterations in Glioma: Insights From Resting-State Functional MRI.

Jun Kanzawa¹, Shiori Amemiya¹, Hidemasa Takao¹

¹Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging

|September 3, 2025

Summary

This summary is machine-generated.

Global signal cross-correlation (GSXC) and amplitude of low-frequency fluctuations (ALFF) reveal distinct glioma characteristics. GSXC is reduced in gliomas, indicating impaired cerebrovascular reactivity, while ALFF changes vary by tumor grade.

Keywords:

amplitude of low‐frequency fluctuations glioma global signal resting‐state functional MRI

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Related Experiment Videos

Last Updated: Sep 9, 2025

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Area of Science:

Neuroimaging
Oncology
Biophysics

Background:

Gliomas are primary brain tumors with significant impact on brain function.
Hemodynamic alterations are key pathological features of gliomas.
Resting-state functional MRI (fMRI) offers insights into brain function and vascularity.

Purpose of the Study:

To characterize hemodynamic alterations in gliomas using global signal cross-correlation (GSXC) and amplitude of low-frequency fluctuations (ALFF).
To investigate the relationship between these metrics and glioma grade.
To explore the diagnostic potential of fMRI-derived metrics in glioma assessment.

Main Methods:

Analysis of resting-state fMRI data from 29 glioma patients.
Calculation of GSXC and ALFF, comparing tumor regions with contralateral homologous areas.
Application of linear mixed-effects models to assess the impact of tumor grade and measurement side.

Main Results:

GSXC was significantly reduced in glioma regions compared to the contralateral hemisphere across all grades.
ALFF was significantly lower in low-grade gliomas but showed no significant difference in high-grade gliomas.
These findings suggest distinct hemodynamic profiles associated with glioma grade.

Conclusions:

GSXC and ALFF provide complementary pathological information for glioma characterization.
Reduced GSXC indicates gliovascular uncoupling and impaired cerebrovascular reactivity.
ALFF variations may reflect differences in tumor vascularity, with potential increases in high-grade gliomas.