Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Hye Jin Lee1, Yu Jin So1, Il-Joo Jo2
1College of Korean Medicine, Woosuk University, Jeonju-si, Republic of Korea.
Phytotherapy Research : PTR
|September 3, 2025
Summary
Natural compounds show promise for managing psoriasis by targeting key inflammatory pathways. They offer a potentially safer, adjunctive treatment option to alleviate symptoms and reduce side effects associated with conventional therapies.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin disease with genetic, immune, and environmental influences.
- It causes physical discomfort and comorbidities like arthritis and cardiovascular issues, creating significant burdens.
- Current treatments have limitations, including side effects and dependency.
Purpose of the Study:
- To review the therapeutic potential of natural compounds for psoriasis.
- To evaluate their ability to modulate key cellular pathways in psoriasis pathogenesis.
- To assess their role as a safer, adjunctive treatment option.
Main Methods:
- Literature review focusing on natural compounds and psoriasis.
- Analysis of studies investigating natural compounds' effects on inflammatory pathways.
- Evaluation of anti-inflammatory, keratinocyte-regulating, and antioxidant properties.
Main Results:
- Natural compounds possess anti-inflammatory, antioxidant, and keratinocyte-regulating properties.
- They influence critical pathways such as the Th17/IL-17 axis and oxidative stress.
- Evidence suggests potential for symptom management and side effect mitigation.
Conclusions:
- Natural compounds may serve as effective adjunctive therapies for psoriasis.
- They offer a potentially safer alternative by addressing underlying mechanisms.
- Further research can optimize their use in managing psoriasis symptoms.
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