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Updated: Sep 9, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy
Aline Linder1, Farah Diab2, Loïc de Pontual3
1Laboratory For Functional Immune Repertoire Analysis, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Abstract:
Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.
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