Related Experiment Video
Updated: Sep 9, 2025

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
Published on: May 31, 2024
Formosulfathiazole: A Structural Revision
Claudio Maestri1,2, Toni Grell3, Fabio Travagin1
1Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Guido Donegani 2, Novara (NO), 28100, Italy.
Abstract:
Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.
More Related Videos
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
08:47Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Related Concept Videos
Preparation and Reactions of Sulfides
Preparation and Reactions of Thiols
Structure and Nomenclature of Thiols and Sulfides
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Diazonium Group Substitution: –OH and –H
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene