Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future...

Area of Science:

• Oncology
• Nanotechnology
• Materials Science

Background:

• Gastric cancer (GC) remains a leading cause of cancer mortality globally.
• Current GC treatments show suboptimal therapeutic efficacy despite advancements.
• Nanomaterials are emerging as potent tools for targeted cancer therapy.

Purpose of the Study:

• To comprehensively review nanoformulations for gastric cancer (GC) treatment.
• To examine the application of nanomaterials in various GC therapeutic strategies.
• To discuss the design principles, challenges, and future prospects of nano-based GC therapies.

Main Methods:

• Review of major nanoformulation types: liposomes, albumin-based NPs, polymer-based NPs, inorganic NPs, and cell-derived nanomaterials.
• Examination of nanoformulations in chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, and combined therapies for GC.
• Analysis of design concepts and underlying principles of nanoformulations in GC treatment.

Main Results:

• Various nanoformulations demonstrate potential for targeted drug delivery in GC.
• Nanoformulations are being explored across multiple GC treatment modalities.
• Key design principles facilitate enhanced therapeutic outcomes and reduced toxicity.

Conclusions:

• Nanoformulations represent a significant advancement in gastric cancer (GC) treatment strategies.
• Targeted delivery via nanomaterials improves therapeutic efficacy and minimizes side effects.
• Continued research into nanoformulation design and application holds promise for overcoming GC treatment challenges.