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Related Concept Videos

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

545
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
545
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

557
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
557
General Anesthesia: Overview01:24

General Anesthesia: Overview

283
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
283
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

772
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
772
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

196
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
196
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1.2K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
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Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
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Vibration-Assisted Anesthesia Reduces Pain in Dermatologic Procedures: A Split-Lesion Study.

Rohan Manoj1, Amod Apastamb, Aayush Gupta

  • 1All authors are affiliated with the Department of Dermatology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

Vibration-assisted anesthesia significantly reduces pain during dermatologic procedures. This novel approach offers a non-pharmacologic option, improving patient experience and comfort with high success rates.

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Area of Science:

  • Dermatology
  • Pain Management
  • Anesthesia

Background:

  • Vibration-assisted anesthesia utilizes gate control theory for non-pharmacologic pain reduction.
  • Limited real-world data exists for vibration-assisted anesthesia in dermatology.

Purpose of the Study:

  • To assess the effectiveness of a new wearable vibrating kinetic anesthesia (VKA) device.
  • To evaluate pain reduction during dermatologic procedures using a split-lesion, intrapatient-controlled design.

Main Methods:

  • Prospective observational study with 629 patients undergoing dermatologic procedures.
  • Comparison of procedures on sites with and without VKA.
  • Pain assessment via Visual Analog Scale (VAS), Numeric Rating Scale (NRS), and Modified Verbal Rating Scale (MVRS).

Main Results:

  • VKA significantly reduced pain: mean ΔVAS = 2.61, ΔNRS = 2.44 (p < .001).
  • Large effect sizes (Cohen's d > 1.0) and high composite success rate (81.5%).
  • Patients preferred VKA in 94.6% of cases, with a shift in pain descriptors.

Conclusions:

  • Vibration-assisted anesthesia is effective in reducing procedural pain in dermatology.
  • The VKA device significantly improves the patient experience during dermatologic procedures.