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Related Experiment Video

Updated: Sep 9, 2025

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Bidirectional Relationship between the BDNF Gene and miRNA: Implications for PD Pathogenesis.

Ajay Elangovan1, Mahalaxmi Iyer2, Dibbanti HariKrishna Reddy3

  • 1Neurobiology (Ageing and Pediatric) Laboratory, Department of Zoology, Central University of Punjab, Bathinda 151401, Punjab, India.

ACS Chemical Neuroscience
|September 3, 2025
PubMed
Summary

Brain-derived neurotrophic factor (BDNF) and its pathways are crucial in Parkinson's disease (PD) pathogenesis. Targeting microRNAs (miRNAs) offers a potential therapeutic strategy for PD by modulating these pathways.

Keywords:
BDNF-ASParkinson’s disease (PD)brain-derived neurotrophic factor (BDNF)long noncoding RNA (LncRNA)microRNA (miRNA)

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment.
  • Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase (BDNF/TrkB) are vital for dopaminergic neuron maintenance and plasticity, particularly in the substantia nigra.
  • Downregulation of BDNF/TrkB expression is linked to cognitive impairments in PD, and long noncoding RNAs (lncRNAs) like BDNF-AS are implicated in PD pathogenesis.

Purpose of the Study:

  • To review the multifaceted roles of the BDNF gene, its receptors, and LncRNA BDNF-AS in Parkinson's disease.
  • To explore the involvement of the BDNF/TrkB signaling pathway in PD-related cognitive decline.
  • To investigate the potential of miRNA targets as therapeutic interventions for PD.

Main Methods:

  • Literature review synthesizing findings on BDNF, BDNF/TrkB, and LncRNA BDNF-AS in PD.
  • Analysis of studies investigating the expression and function of these molecules in the context of PD pathogenesis.
  • Exploration of miRNA-mediated regulation within the BDNF signaling pathway.

Main Results:

  • BDNF plays a dual role in PD, acting as both a protector and modulator of dopaminergic neurons.
  • Downregulation of BDNF/TrkB contributes to cognitive impairments observed in Parkinson's disease.
  • LncRNA BDNF-AS influences PD pathogenesis by regulating the BDNF neurotrophin signaling pathway and its miRNA targets.

Conclusions:

  • The BDNF gene, its receptors, and LncRNA BDNF-AS are significantly involved in the pathogenesis of Parkinson's disease.
  • MicroRNA targets within the BDNF pathway represent a promising avenue for developing novel therapeutic strategies for PD.
  • Further research into miRNA-based interventions could lead to effective treatments for the non-motor symptoms of PD.