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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Cobalt-Catalyzed Cross-Electrophile Dehydroxylative and Desulfonylative Allylation
Haiyan Dong1,2, Xinran Dai2, Xinran Ding2
1School of Chemistry and Materials Engineering, Anhui Engineering Research Center for Photoelectrocatalytic Electrode Materials, Huainan Normal University, Huainan, Anhui 232038, P. R. China.
None:
Herein, we report a step- and atom-economical allylation reaction of allyl alcohols with activated alkyl bromides by merging cross-electrophile and dehydroxylative coupling under the catalysis of cobalt. This reaction delivers a method to synthesize multisubstituted γ,δ-unsaturated α,α-difluoro amides and carboxylates in a highly regio- and diastereoselective manner. Furthermore, we also demonstrate the viability of a cobalt-catalyzed cross-electrophile desulfonylative allylation in a proof-of-concept study.
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