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Updated: Sep 9, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Application of mesenchymal stem cells in ferroptosis-related diseases
Xianmei Zhong1,2, Xue Zhang3, Yuxuan Zhu4
1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Abstract:
Modern medicine has achieved groundbreaking advancements in disease diagnosis and treatment, yet significant challenges remain in managing conditions such as age-related diseases, tumors, autoimmune disorders, and neurological conditions. Conventional drug therapies often suffer from inadequate targeting, severe toxic side effects, and limited therapeutic efficacy, leading to adverse clinical outcomes such as disease recurrence and organ dysfunction. In recent years, mesenchymal stem cells (MSCs) have demonstrated transformative potential in regenerative medicine and disease therapy. Leveraging their multipotent differentiation potential, immunomodulatory properties, and paracrine functions, MSCs offer innovative strategies by enhancing tissue repair and microenvironmental homeostasis. Notably, ferroptosis-a newly identified form of regulated cell death-has emerged as a critical research frontier. MSCs and their exosomes exhibit a remarkable ability to modulate ferroptosis by regulating iron ions and lipid peroxide levels. This review provides an in-depth analysis of the molecular pathways through which MSCs influence ferroptosis. Additionally, it explores recent advances in ferroptosis regulation in transplanted MSCs, shedding light on their clinical applicability. In summary, this work underscores the therapeutic promise of MSCs in treating ferroptosis-associated diseases.
Insights
Mesenchymal stem cells (MSCs) show promise for treating diseases linked to ferroptosis, a type of cell death. MSCs regulate ferroptosis, offering new therapeutic avenues for various conditions.
Area of Science:
- Biomedical Science
- Cell Biology
- Regenerative Medicine
Background:
- Conventional therapies face challenges in targeting diseases like cancer and neurological disorders, often causing side effects.
- Ferroptosis, a regulated cell death pathway, is increasingly recognized as crucial in disease pathogenesis.
- Mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory capabilities, offering potential therapeutic benefits.
Purpose of the Study:
- To analyze the molecular mechanisms by which MSCs influence ferroptosis.
- To review recent advancements in regulating ferroptosis using transplanted MSCs.
- To highlight the clinical potential of MSCs in treating ferroptosis-associated diseases.
Main Methods:
- Literature review focusing on MSCs and ferroptosis.
- Analysis of molecular pathways involved in MSC-mediated ferroptosis regulation.
- Examination of studies on transplanted MSCs for ferroptosis control.
Main Results:
- MSCs and their exosomes can modulate ferroptosis by affecting iron and lipid peroxide levels.
- Understanding MSCs' role in ferroptosis opens new therapeutic strategies.
- Transplanted MSCs demonstrate potential in managing ferroptosis-related conditions.
Conclusions:
- MSCs offer a promising therapeutic approach for ferroptosis-associated diseases.
- Further research into MSCs and ferroptosis regulation can advance clinical applications.
- This review underscores the significant therapeutic potential of MSCs in regenerative medicine.
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