Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

4.8K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loneliness, affectivity and psychological distress in people living alone during the COVID-19 pandemic: a cluster analysis.

Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS·2026
Same author

Epidemiology of Acute Chagas Disease in the Amazon: Association between the açaí production chain and case reports in Pará state, Brazil.

Revista da Sociedade Brasileira de Medicina Tropical·2026
Same author

Positive expectations and health behaviors among the adult population: A systematic review and meta-analysis.

Journal of health psychology·2026
Same author

Ascorbic Acid Prevents Efavirenz-Induced Anxiety-Like Behavior and Brain Oxidative Stress in Zebrafish.

Oxidative medicine and cellular longevity·2025
Same author

Anxiety and Fryes: A Novel Model to Study Anxiety in Zebrafish Larvae.

Zebrafish·2025
Same author

Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system.

Social cognitive and affective neuroscience·2024

Related Experiment Video

Updated: Sep 9, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K

Effects of ayahuasca in preclinical studies with animals: a systematic review.

A Walsh-Monteiro1, S Morato2, F A R Uribe3

  • 1Laboratório de Neuroquímica e Comportamento, Coordenação de Ciências Biológicas, Campus Tucuruí, Instituto Federal do Pará, Tucuruí, PA, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologica
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

Ayahuasca (Aya) significantly alters animal motor and cognitive behavior, particularly affecting the serotonergic system. More standardized preclinical studies are needed to assess its therapeutic safety and neurochemical effects.

More Related Videos

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

Related Experiment Videos

Last Updated: Sep 9, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Ayahuasca (Aya) is a psychoactive Amazonian brew with potential therapeutic applications.
  • Preclinical research is crucial for understanding its effects and safety before human trials.

Purpose of the Study:

  • To systematically review the effects of ayahuasca (Aya) on behavior and neurochemistry in animal models.
  • To identify gaps in current preclinical research on Aya.

Main Methods:

  • Systematic review of 2,359 documents (2012-2022) from major scientific databases.
  • Adherence to PRISMA protocol and Cochrane Handbook for rigorous study selection.
  • Inclusion of 14 articles meeting predefined criteria for final analysis.

Main Results:

  • Ayahuasca (Aya) induces significant alterations in animal motor and cognitive functions.
  • Observed behavioral changes are linked to the serotonergic system.
  • These effects may relate to symptoms seen in depression and schizophrenia.

Conclusions:

  • Ayahuasca (Aya) demonstrates notable behavioral and neurochemical effects in animal models.
  • There is a need for more methodologically standardized preclinical studies.
  • Further research is required for a safer assessment of Aya's therapeutic potential.