Jove
Visualize
Contact Us

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

4.8K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.8K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Effects Of Ayahuasca In Preclinical Studies With Animals: A Systematic Review.
  1. Home
  3. Effects Of Ayahuasca In Preclinical Studies With Animals: A Systematic Review.

Related Experiment Video

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K

Effects of ayahuasca in preclinical studies with animals: a systematic review.

A Walsh-Monteiro1, S Morato2, F A R Uribe3

  • 1Laboratório de Neuroquímica e Comportamento, Coordenação de Ciências Biológicas, Campus Tucuruí, Instituto Federal do Pará, Tucuruí, PA, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologica
|September 3, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Ayahuasca (Aya) significantly alters animal motor and cognitive behavior, particularly affecting the serotonergic system. More standardized preclinical studies are needed to assess its therapeutic safety and neurochemical effects.

More Related Videos

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

Related Experiment Videos

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Ayahuasca (Aya) is a psychoactive Amazonian brew with potential therapeutic applications.
  • Preclinical research is crucial for understanding its effects and safety before human trials.

Purpose of the Study:

  • To systematically review the effects of ayahuasca (Aya) on behavior and neurochemistry in animal models.
  • To identify gaps in current preclinical research on Aya.

Main Methods:

  • Systematic review of 2,359 documents (2012-2022) from major scientific databases.
  • Adherence to PRISMA protocol and Cochrane Handbook for rigorous study selection.
  • Inclusion of 14 articles meeting predefined criteria for final analysis.

Main Results:

  • Ayahuasca (Aya) induces significant alterations in animal motor and cognitive functions.
  • Observed behavioral changes are linked to the serotonergic system.
  • These effects may relate to symptoms seen in depression and schizophrenia.

Conclusions:

  • Ayahuasca (Aya) demonstrates notable behavioral and neurochemical effects in animal models.
  • There is a need for more methodologically standardized preclinical studies.
  • Further research is required for a safer assessment of Aya's therapeutic potential.