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Interleukin-17 Inhibitors and Early Major Adverse Cardiovascular Events

  • 0Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en 13 Santé, Environnement et Travail)-UMR_S 1085, Rennes, France.
Jama Dermatology +

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September 3, 2025

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September 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Initiating interleukin-17A (IL-17A) inhibitors for psoriasis does not significantly increase the risk of major adverse cardiovascular events (MACEs). This finding holds true across different patient cardiovascular risk levels, suggesting these biologics are safe for heart health.

Area Of Science

  • Cardiovascular Medicine
  • Dermatology
  • Immunology

Background

  • The cardiovascular impact of biologics for psoriasis is not fully understood.
  • Inhibition of the T-helper 17 cell pathway may destabilize atherosclerotic plaques, potentially increasing major adverse cardiovascular events (MACEs).

Purpose Of The Study

  • To assess if initiating interleukin (IL)-17A inhibitors triggers MACEs.
  • To evaluate the association between IL-17A inhibitor initiation and MACEs, using tumor necrosis factor (TNF)-α inhibitors as a comparator.

Main Methods

  • A case-time-control study utilized the French National Health Insurance database (2016-2021).
  • Included patients initiating IL-17A inhibitors (secukinumab, ixekizumab, brodalumab) or TNF-α inhibitors (adalimumab, etanercept).
  • Assessed MACE risk in the 6 months post-initiation compared to a prior 6-month reference period.

Main Results

  • Among 34,241 individuals on IL-17A inhibitors, 381 MACEs were analyzed.
  • Initiation of IL-17A inhibitors showed no significant association with MACEs (OR, 1.40 [95% CI, 0.77-2.54]) compared to TNF-α inhibitors.
  • Results remained consistent across sensitivity analyses and patient cardiovascular risk levels.

Conclusions

  • No significant association was found between MACEs and the initiation of IL-17A inhibitors.
  • The study suggests IL-17A inhibitors are not linked to increased cardiovascular risk in psoriasis patients.
  • A modest risk increase cannot be entirely excluded, warranting continued monitoring.

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