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Updated: May 3, 2026
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The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION
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Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus
Di Jin1, Xun Liu2, Yuwei Wang3
1Department of Rheumatology, Weifang People's Hospital, Weifang, Shandong, China.
Frontiers in Immunology
|September 3, 2025
Summary
Systemic lupus erythematosus (SLE) can cause rare but serious eye problems like retinal vasculitis and optic neuritis. Early diagnosis and treatment with immunosuppressants like methylprednisolone and rituximab can restore vision in affected patients.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune condition affecting multiple organs.
- Ocular manifestations, including retinal vasculitis and optic neuritis, are infrequent but severe SLE complications.
Observation:
- A 26-year-old female with new SLE diagnosis experienced progressive visual impairment.
- The patient presented with concurrent retinal vasculitis and optic neuritis.
Findings:
- Successful treatment involved methylprednisolone and rituximab, leading to substantial visual recovery.
- Literature review indicates diagnostic challenges and varied treatment approaches for ocular SLE.
Implications:
- Highlights the critical need for prompt identification of ocular involvement in SLE patients.
- Aggressive immunosuppressive therapy is crucial for improving visual outcomes and managing SLE-related eye disease.
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