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[Alkaline phosphatase in the blood and lymph in diffuse peritonitis]
Vestnik Khirurgii Imeni I. I. Grekova
|October 1, 1985
Summary
Alkaline phosphatase activity increases in peritonitis, with the lymphatic system playing a larger role in enzyme transport. Thoracic duct drainage effectively reduces this enzyme intoxication.
Area of Science:
- Biochemistry
- Physiology
- Surgical Pathophysiology
Context:
- Experimental peritonitis in dogs and clinical observations in human patients with thoracic duct drainage.
- Investigates the role of alkaline phosphatase (ALP) in systemic intoxication during peritonitis.
- Compares ALP transport via blood and lymph under normal and pathological conditions.
Purpose:
- To elucidate the transport pathways of alkaline phosphatase (ALP) in experimental peritonitis.
- To evaluate the efficacy of thoracic duct drainage as a therapeutic intervention for ALP-mediated intoxication.
- To quantify the contribution of the lymphatic system to ALP transport during peritonitis.
Summary:
- Alkaline phosphatase (ALP) activity was assessed in blood and lymph of dogs with experimental peritonitis and in human patients with and without thoracic duct drainage.
- Results indicate significant enzyme intoxication in peritonitis, with the lymphatic route becoming a major pathway for ALP transport.
- Drainage of the thoracic duct demonstrated a significant detoxicating effect, evidenced by decreased ALP activity.
Impact:
- Highlights the lymphatic system's critical role in the pathophysiology of peritonitis-induced enzyme intoxication.
- Provides evidence supporting thoracic duct drainage as a viable clinical strategy for managing peritonitis.
- Offers insights into the biochemical mechanisms underlying systemic inflammation and detoxification.