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Updated: Sep 9, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Advances in copper homeostasis and copper dysregulation in diseases
Mengmeng Tang1, Jiamei Zhang1, Min Yu1
1Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Abstract:
Copper (Cu), as an essential trace element in the human body, plays an important supporting role in the maintenance of various basic biological functions. Copper homeostasis in the human body is tightly regulated, and an imbalance in copper homeostasis may lead to various diseases. Recent studies have proposed the concept of cuproptosis, suggesting that cuproptosis is a regulated cell death triggered by excessive intracellular accumulation of copper, which is a recently discovered form of cell death different from the known cell death mechanisms. In this review, we systematically detailed the research progress on copper metabolism and homeostasis, cuproptosis mechanism and the relationship between copper metabolism imbalance and related diseases, aiming to provide ideas for exploring the therapeutic strategies of various diseases based on copper metabolism imbalance.
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