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Personality and epigenetic aging: A multi-cohort and multi-clock study.

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Higher conscientiousness is linked to slower biological aging, as measured by advanced epigenetic clocks. This personality trait may influence healthspan and longevity.

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Area of Science:

  • Gerontology
  • Behavioral Science
  • Epigenetics

Background:

  • Epigenetic clocks quantify biological aging and correlate with health outcomes like mortality.
  • Understanding factors influencing biological aging is crucial for promoting healthspan.

Purpose of the Study:

  • To investigate the relationship between personality traits and epigenetic aging.
  • To determine if specific personality traits are associated with slower or faster biological aging.

Main Methods:

  • Meta-analysis of data from over 6000 participants across three large longitudinal studies.
  • Assessment of personality traits, demographic factors, and multiple generations of epigenetic clocks (Hannum, Horvath, PhenoAge, GrimAge, DunedinPoAM38/DunedinPace).

Main Results:

  • Conscientiousness showed a consistent association with slower epigenetic aging, particularly for second- and third-generation clocks.
  • Other personality traits did not exhibit consistent associations with the epigenetic clocks.
  • Agreeableness was linked to slower epigenetic aging in older adults but not younger adults.

Conclusions:

  • Conscientiousness is a significant personality correlate of slower epigenetic aging, especially when using health-outcome-based epigenetic clocks.
  • Personality may play a role in modulating biological aging processes and potentially healthspan.