Prognostic role of Naples prognostic score in lung cancer: a meta-analysis
Junrong Yang1, Hui Li1, Liangqin Li1
1Department of Thoracic Surgery, People's Hospital of Deyang City, Deyang, China.
Purpose:
To clarify the association of pretreatment Naples prognostic score (NPS) with long-term survival among lung cancer patients.
Methods:
EMBASE, Web of Science, PubMed and CNKI databases were searched up to April 16, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined and subgroup analysis stratified by the pathological type and treatment was performed.
Results:
Twelve studies with 3089 patients were included and most patients were from China. Pooled results demonstrated that elevated NPS was related to poor OS (HR = 2.82, 95% CI: 1.88-4.25, P < 0.001), PFS (HR = 2.75, 95% CI: 1.89-4.01, P < 0.001) and CSS (HR = 3.5, 95% CI: 1.6-7.9, P = 0.002). Besides, subgroup analysis based on the pathological type [non-small cell lung cancer (NSCLC) vs small cell lung cancer (SCLC)] and treatment (surgery vs non-surgery) manifested similar results.
Conclusion:
Pretreatment NPS is associated with long-term prognosis in lung cancer and patients with elevated NPS are more likely to experience poor survival. However, more studies are needed to verify above findings due to limitations in this meta-analysis.
