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The DNA Helix

The DNA Helix

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Updated: Sep 9, 2025

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Design principles for construction of DNA-based nanostructures.

Chunfa Chen¹, Xiaoyu Xia¹, Cheng Tian¹

¹Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Advanced Drug Delivery Reviews

|September 3, 2025

Summary

This summary is machine-generated.

This review explores DNA nanotechnology, detailing methods for building DNA nanostructures from simple tiles to complex scaffolds. It covers applications in therapy, biosensing, and computation, and discusses DNA aggregates and self-assembly.

Keywords:

DNA nanotechnology Nanomotifs Nanostructures Self-assembly Tiles

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Last Updated: Sep 9, 2025

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

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Published on: April 12, 2019

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Published on: September 27, 2019

Area of Science:

Biotechnology
Nanotechnology
Molecular Engineering

Background:

DNA nanotechnology leverages DNA's programmability for creating nanostructures.
These nanostructures have diverse applications in medicine, sensing, and computation.

Purpose of the Study:

To review fundamental strategies for constructing DNA nanostructures.
To survey advanced DNA structures, computational aspects, and DNA-based aggregates.

Main Methods:

Design of basic DNA building blocks (e.g., DX, TX tiles, T-junctions).
Construction of complex scaffolds (DNA origami, single-stranded tiles).
Assembly into extended arrays (1D/2D/3D) and aggregates (hydrogels).

Main Results:

Elucidation of design and construction logic for static and dynamic DNA nanostructures.
Introduction to algorithmic self-assembly and DNA-based aggregates.
Overview of DNA nanostructures from microscopic to macroscopic scales.

Conclusions:

DNA nanotechnology offers versatile strategies for creating sophisticated nanostructures.
The field enables applications spanning from molecular computation to macroscopic materials.
This review provides a comprehensive guide to DNA nanostructure construction and potential.