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Updated: Sep 9, 2025

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
Published on: January 16, 2020
Research advances in protein prenylation in cardiovascular diseases
Wen Shi1, Yuxiao Chen1, Xuan Zhang1
1Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Abstract:
Protein prenylation is an evolutionarily conserved post-translational modification encompassing farnesylation and geranylgeranylation. This modification is fundamental to the precise regulation of protein localization, activity, and stability, thereby underpinning critical cellular functions. Aberrant prenylation is closely associated with cardiovascular diseases and influences a spectrum of pathological mechanisms in a complex manner. This review summarises current findings on the roles and mechanisms of prenylation in cardiovascular diseases, outlines its cellular functions, and highlights recent advances in drug development and detection technologies related to prenylation.
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