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Noninfectious pulmonary complications after hematopoietic cell transplantation: a comprehensive review
Christopher Bertini1, Felipe Soto2, Rebecca Brown3
1Divisions of Pulmonary and Critical Care Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA.
Abstract:
Hematopoietic stem cell transplant (HSCT) is a cornerstone for the treatment of high-risk hematologic malignancies. The efficacy of HSCT is limited by transplant-related complications, particularly pulmonary complications. Broadly speaking, the myriads of non-infectious complications that occur after HSCT are less completely understood than infectious complications despite contributing to significant morbidity and mortality. This review covers all major non-infectious pulmonary complications (NIPCs), offering clinical context regarding NIPCs presentation and provoking events while highlighting pathogenesis, knowledge gaps, and emerging therapies.
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