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Seasonal Variation in Diuretic-Induced Dehydration Using Spontaneous Reports of Adverse Events
Satoshi Nakao1,2, Mika Maezawa1, Kohei Shiota1
1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
Biological & Pharmaceutical Bulletin
|September 3, 2025
Summary
Diuretic-induced dehydration (DID) is common in winter and summer. Healthcare providers should advise patients taking diuretics to maintain adequate water intake year-round, especially during colder months.
Area of Science:
- Pharmacovigilance
- Clinical Medicine
- Public Health
Background:
- Diuretics are essential treatments for heart failure (HF) and hypertension.
- Understanding adverse drug events like diuretic-induced dehydration (DID) is crucial for patient safety.
Purpose of the Study:
- To analyze seasonal variations in diuretic-induced dehydration (DID) using real-world data.
- To identify peak reporting periods for DID to inform clinical practice.
Main Methods:
- Retrospective analysis of the Japanese Adverse Drug Event Report (JADER) database.
- Examined monthly reporting ratios (RR) of DID for 11 diuretics from January 2003 to December 2023.
Main Results:
- Diuretic-induced dehydration (DID) was most frequently reported in January, followed by August.
- DID reports were notably common during winter months (December, January, February).
Conclusions:
- Diuretic-induced dehydration (DID) occurs in both winter and summer.
- Healthcare providers must recommend adequate water intake for patients on diuretics throughout the year, including winter, to prevent dehydration.
Keywords:
Japanese Adverse Drug Event Report databaseadverse eventdehydrationdiureticseasonal variationMore Related Videos
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