Seasonal Variation in Diuretic-Induced Dehydration Using Spontaneous Reports of Adverse Events

Diuretics have long been central to the treatment of heart failure (HF) and hypertension, and are widely used in clinical settings. Herein, we performed a retrospective analysis of seasonal variations in diuretic-induced dehydration (DID) using the Japanese Adverse Drug Event Report (JADER) database, a platform that presents data on real-world clinical practice. A total of 11 diuretics prescribed in Japan, categorized into six groups, were included. The monthly reporting ratio (RR) of DID in the JADER database was determined from January 2003 to December 2023. DID was most common in January, followed by August. Furthermore, it was frequently reported during the winter months of December, January, and February. It is important for healthcare providers to understand that DID is common in both winter and summer, and thus recommend adequate water intake even in the former for patients taking diuretics. These findings can contribute to the management of dehydration in patients taking diuretics and are beneficial to healthcare professionals involved in the treatment of HF and hypertension.