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[Disseminated intravascular coagulation associated with solid cancers].

Yoshinobu Seki1,2

  • 1Department of Hematology, Niigata University Medical and Dental Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

Disseminated intravascular coagulation (DIC) is a cancer complication. Early diagnosis and treatment of DIC in solid cancer patients are crucial for improving prognosis and quality of life.

Keywords:
Disseminated intravascular coagulationJSTH clinical practice guideline 2024Quality of lifeSolid cancer

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Area of Science:

  • Oncology
  • Hematology
  • Thrombosis

Background:

  • Disseminated intravascular coagulation (DIC) is a paraneoplastic syndrome associated with solid cancers.
  • DIC in cancer patients can manifest as chronic or acute, severe conditions.
  • Cancer-associated thrombosis (CAT) involves a hypercoagulable state, leading to thrombotic events like DVT, PE, and cerebral infarction.

Purpose of the Study:

  • To review the pathogenesis, diagnosis, and treatment of DIC in solid cancers.
  • To provide guidance based on the 2024 Japanese Clinical Practice Guidelines for DIC management.

Main Methods:

  • Literature review focusing on DIC in solid cancers.
  • Analysis of the 2024 Japanese Society on Thrombosis and Hemostasis Clinical Practice Guidelines.

Main Results:

  • Solid cancers commonly present with chronic DIC, balancing thrombocytopenia and platelet production.
  • Rapid-onset, severe DIC can occur with certain disseminated cancers.
  • Prompt diagnosis and treatment of DIC are vital for patient outcomes.

Conclusions:

  • DIC is a significant concern in solid cancer management.
  • Understanding DIC pathogenesis and adhering to clinical guidelines are essential.
  • Effective management of DIC can improve prognosis and quality of life for cancer patients.